Major research activities

Cell-to-Cell and Muscle-to-Other Organ Cross-talk
We study how skeletal muscle acts as both a local and systemic communicator by secretion of various factors, influencing the health and function of the entire body. Our research focuses on the intricate cellular communication between muscle stem cells, neighbouring niche cells, and non-muscle tissues. By discovering the molecular signals and cellular interactions that maintain muscle homeostasis, we aim to understand how these networks break down during aging and diseases.

Skeletal Muscle Regeneration, Inflammaging and Muscle-wasting
We investigate how muscle’s regenerative capacity declines with age and in muscle-wasting conditions such as sarcopenia, cachexia, and muscular dystrophies. Using mouse genetics, molecular/cell biology tools coupled with high throughput computational analyses, we aim to identify the key cellular and molecular changes that drive muscle regeneration and their dysfunction in muscle-wasting diseases.

Transcriptional and Epigenetic Regulation of Muscle Stem Cell Survival and Identity
Our lab examines how transcriptional and epigenetic mechanisms maintain the identity and survival of muscle stem cells. These regulatory processes ensure that stem cells activate, self-renew, and differentiate properly during muscle repair. By understanding how these mechanisms are altered during aging and disease, we aim to develop new therapeutic approaches to enhance regeneration and improve muscle health.